![]() Leisure MVPA was associated with the most health benefits, nonleisure MVPA with little health benefits, and occupational MVPA with no health benefits. No linear association between MVPA and all-cause mortality or MACE was found for healthy individuals ( P = 0.36) and individuals with CVRF ( P = 0.86), but a linear association was demonstrated for individuals with CVD ( P = 0.04). ![]() ![]() The main analyses were stratified on baseline health status and adjusted for age, sex, income, education, alcohol consumption, smoking, protein, fat and carbohydrate intake, kidney function, arrhythmias, hypothyroid, lung disease, osteoarthritis, and rheumatoid arthritis. Cox regression was used to estimate hazard ratios (HRs), 95% confidence intervals (CIs) and P values. Primary outcome was a composite of incident MACE and all-cause mortality during follow-up. ![]() Individuals were categorized into “inactive” and 4 quartiles of least (Q1) to most (Q4) active based on self-reported MVPA volumes. A total of 142,493 participants of the Lifelines Cohort Study were stratified at baseline as (1) healthy (2) CVRF or (3) CVD. A cohort study was performed in the 3 northern provinces of the Netherlands, in which data were collected between 20, with a median follow-up of 6.8 years (Q 25 5.7 Q 75 7.9). ![]()
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